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Скандалы, громкие разоблачения, признания под гнетом обличающих доказательств, сломанные судьбы, слезы несостоявшихся стартов — это все мельдоний. Положительные допинг-пробы на содержание этого препарата, который первоначально не входил в список запрещенных, вывели из строя многих ничего не подозревающих спортсменов.

«Устройство» мельдония: почему российские спортсмены выиграют суд у WADA

25 октября 2017 г.

     РИА НОВОСТИ

Лекарственный препарат мельдоний, запрещенный Всемирным антидопинговым агентством

Красивую с химической точки зрения молекулу милдроната создал латвийский химик Иварс Калвиньш. Ученый понял, что как только организм ощущает стресс, он синтезирует внутри себя вещество гамма-бутиробетаин, или ГББ (gamma butyrobetaine, GBB). Дальше гамма-бутиробетаин переходит в картинитин — витаминоподобное соединение, которое участвует в окислении жирных кислот. Когда окисление заблокировано, жирных кислот не хватает, организм дает сигнал: начать производить энергию другим путем — через глюкозу. Тогда при поддержании высокого уровня энергии организму нужно гораздо меньше кислорода.

© РИА Новости / Оксана Джадан Директор латвийского Института органического синтеза Иварс Калвиньш

Калвиньш исследовал маленькую молекулу ГББ. Тут ведь и менять-то нечего, только четыре атома углерода в цепочке. И все-таки один из них удалось заменить на азот.

В результате он получил идеальную молекулу. При попадании в организм она делала свое дело и, не смешиваясь ни с чем, уходила из организма.

«Я специально сделал милдронат неразлагаемым. Получилась копия углеродного регулятора ответа на стресс. В том числе энергетический стресс, когда нет кислорода. Потом во многих лабораториях мира химики пытались нас обойти, сделать что-то получше. Но пока почти за 50 лет это никому не удалось», — поясняет Калвиньш.

© Иллюстрация РИА Новости . А.Полянина Отличие молекулы милдроната от гамма-бутиробетаина (ГББ)

Является ли милдронат допингом? Нет, и никто этого не утверждает. Вот и в документах WADA написано, что милдронат просто корригирует, то есть улучшает метаболизм. Однако если спортсмен не будет тренироваться, никакой милдронат ему не поможет.

Точно так же, как и красное мясо, например. Если спортсмен будет есть этот продукт, у него увеличатся мышцы. Если же мясо будет есть человек, который спортом не занимается, — оно будет иметь только вкусовой и энергетический смысл, притом что изменения в метаболизме будут наблюдаться. Так чем же употребление мяса отличается от приема милдроната?

© РИА Новости / Павел Лисицын Лекарственный препарат мельдоний, продающийся под торговой маркой милдронат, с 1 января 2016 года запрещен Всемирным антидопинговым агентством (WADA)

Принцип WADA состоит в том, что эта организация запрещает все, что употребляется часто. Смысл таков: если употребляется часто — значит, помогает, а поэтому является допингом. Но с этой точки зрения может быть запрещено и употребление обычной воды!

«Переводя ход метаболизма с одних рельсов на другие: милдронат защищает организм от последствий перегрузок, — объясняет  Калвиньш. —  С его помощью вы не бежите быстрее или дольше, но можете спокойно на следующий день повторить свою тренировку. Спортсмены все время преодолевают усталость, преодолевают сами себя. Поэтому самые волевые получают серьезное повреждение здоровья, а иногда и диагноз „внезапная смерть“. Например, из 3500 спортсменов, которые занимаются баскетболом на уровне колледжа, умирает один в год. В случае приема милдроната — клетки, сердце и мышцы защищены. Я бы не запрещал этот препарат, а наоборот, рекомендовал бы его принимать абсолютно всем спортсменам».

© РИА Новости / Антон Денисов Мария Шарапова (Россия) в четвертьфинальном матче одиночной встречи против Анетт Контавейт (Эстония) на турнире WTA Porsche Tennis Grand Prix 2017 в Штутгарте

Но самое интересное начинается, когда речь заходит о том, как милдронат выводится из организма. Дело в том, что эта молекула из-за особого сходства с гамма-бутиробетаином может циркулировать в организме до года! Так происходит, потому что нужные белки, ферменты и сахара организм извлекает из мочи обратно, чтобы не потерять ценные вещества. Этот процесс давно известен, он называется канальцевой реабсорбцией.

© Иллюстрация РИА Новости . А.Полянина Анимация изображает процесс канальцевой реабсорбции, то есть обратного всасывания воды и веществ из содержащейся в просвете канальцев мочи в лимфу и кровь.

В каждом отдельном случае обратное всасывание происходит по индивидуальному расписанию. Можно не употреблять милдронат три, шесть, 12 месяцев, и тем не менее допинг-проба определит его наличие в организме.

«К сожалению, изначально WADA основывалось на очень слабых знаниях о молекуле милдроната. Потом они связались со мной, а я сразу сказал им, что малые концентрации будут существовать в организме рекордно долгое время, а им будет трудно оправдаться в суде. В мае специалисты WADA опубликовали исследование, где признались, что при проведении чистого эксперимента было доказано присутствие мельдония в моче через полгода у людей, которые употребляли его всего лишь неделю. Теперь они просто разводят руками. А у российских спортсменов есть все основания выиграть судебные процессы против WADA», — считает Калвиньш.

© РИА Новости / Оксана Джадан Академик Иварс Калвиньш

Конечно, при проведении исследований вполне могла бы сработать идея поиска определенной концентрации милдроната. Как убедились специалисты WADA, концентрация после однократного введения препарата оказалась в 18 раз выше той, которую обнаружили у россиян. Об этом предупреждал и создатель молекулы. Но, вероятно, желание обнаружить хотя бы что-то запрещенное было таким сильным, что научным подходом решили пренебречь.

Постскриптум от Admin

Кто может знать больше и сказать лучше и полнее о своём изобретении, чем не его автор? Именно  поэтому я решил напечатать эту статью, когда она попала мне на глаза, хотя на тему допинга писал ранее (здесь) и возвращаться к этой теме не планировал. 

Единственное, что вызывает недоумение, это отсутствие должной реакции наших спортивных чиновников на допинговый скандал с нашими спортсменами. Хотя удивляться тут особо нечему, скорее всего всё закончится очередными беззубыми угрозами в адрес функционеров ВАДА и МОК. Покалеченные судьбы наших спортсменов их волнуют, похоже, в последнюю очередь, что называется, своя рубашка ближе к телу.

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    • admin:

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    • admin:

      Thank you! About theme and more I recommend reading «For the first time on the site» on the main page of the site (answers on questions ).

      With respect. Admin

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